Establishment of a Patient-Derived, Magnetic Levitation-Based, Three-Dimensional Spheroid Granuloma Model for Human Tuberculosis
TB is a highly infectious disease, with granulomas as its hallmark. Granulomas play an important role in the control of M. tuberculosis
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2021-08-01
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| Series: | mSphere |
| Online Access: | https://journals.asm.org/doi/10.1128/mSphere.00552-21 |
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doaj-b3f1a5f1eb7747178c7f7312ef5a57502021-09-21T19:41:35ZengAmerican Society for MicrobiologymSphere2379-50422021-08-016410.1128/mSphere.00552-21Establishment of a Patient-Derived, Magnetic Levitation-Based, Three-Dimensional Spheroid Granuloma Model for Human TuberculosisLeigh A. Kotze0https://orcid.org/0000-0002-2019-8777Caroline G. G. Beltran1Dirk Lang2Andre G. Loxton3Susan Cooper4Maynard Meiring5Coenraad F. N. Koegelenberg6Brian W. Allwood7Stephanus T. Malherbe8Andriette M. Hiemstra9Brigitte Glanzmann10Craig Kinnear11Gerhard Walzl12Nelita du Plessis13DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaConfocal and Light Microscopy Imaging Facility, University of Cape Town, Cape Town, South AfricaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaConfocal and Light Microscopy Imaging Facility, University of Cape Town, Cape Town, South AfricaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDivision of Pulmonology, Department of Medicine, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South AfricaDivision of Pulmonology, Department of Medicine, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South AfricaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa TB is a highly infectious disease, with granulomas as its hallmark. Granulomas play an important role in the control of M. tuberculosishttps://journals.asm.org/doi/10.1128/mSphere.00552-21 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Leigh A. Kotze Caroline G. G. Beltran Dirk Lang Andre G. Loxton Susan Cooper Maynard Meiring Coenraad F. N. Koegelenberg Brian W. Allwood Stephanus T. Malherbe Andriette M. Hiemstra Brigitte Glanzmann Craig Kinnear Gerhard Walzl Nelita du Plessis |
| spellingShingle |
Leigh A. Kotze Caroline G. G. Beltran Dirk Lang Andre G. Loxton Susan Cooper Maynard Meiring Coenraad F. N. Koegelenberg Brian W. Allwood Stephanus T. Malherbe Andriette M. Hiemstra Brigitte Glanzmann Craig Kinnear Gerhard Walzl Nelita du Plessis Establishment of a Patient-Derived, Magnetic Levitation-Based, Three-Dimensional Spheroid Granuloma Model for Human Tuberculosis mSphere |
| author_facet |
Leigh A. Kotze Caroline G. G. Beltran Dirk Lang Andre G. Loxton Susan Cooper Maynard Meiring Coenraad F. N. Koegelenberg Brian W. Allwood Stephanus T. Malherbe Andriette M. Hiemstra Brigitte Glanzmann Craig Kinnear Gerhard Walzl Nelita du Plessis |
| author_sort |
Leigh A. Kotze |
| title |
Establishment of a Patient-Derived, Magnetic Levitation-Based, Three-Dimensional Spheroid Granuloma Model for Human Tuberculosis |
| title_short |
Establishment of a Patient-Derived, Magnetic Levitation-Based, Three-Dimensional Spheroid Granuloma Model for Human Tuberculosis |
| title_full |
Establishment of a Patient-Derived, Magnetic Levitation-Based, Three-Dimensional Spheroid Granuloma Model for Human Tuberculosis |
| title_fullStr |
Establishment of a Patient-Derived, Magnetic Levitation-Based, Three-Dimensional Spheroid Granuloma Model for Human Tuberculosis |
| title_full_unstemmed |
Establishment of a Patient-Derived, Magnetic Levitation-Based, Three-Dimensional Spheroid Granuloma Model for Human Tuberculosis |
| title_sort |
establishment of a patient-derived, magnetic levitation-based, three-dimensional spheroid granuloma model for human tuberculosis |
| publisher |
American Society for Microbiology |
| series |
mSphere |
| issn |
2379-5042 |
| publishDate |
2021-08-01 |
| description |
TB is a highly infectious disease, with granulomas as its hallmark. Granulomas play an important role in the control of
M. tuberculosis |
| url |
https://journals.asm.org/doi/10.1128/mSphere.00552-21 |
| work_keys_str_mv |
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