Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

I<sub>Kr</sub> current, a major component of cardiac repolarization, is mediated by human <i>Ether-à-go-go</i>-Related Gene (hERG, K<sub>v</sub>11.1) potassium channels. The blockage of these channels by pharmacological compounds is associated to drug-induced long...

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Bibliographic Details
Main Authors: Stephan De Waard, Jérôme Montnach, Barbara Ribeiro, Sébastien Nicolas, Virginie Forest, Flavien Charpentier, Matteo Elia Mangoni, Nathalie Gaborit, Michel Ronjat, Gildas Loussouarn, Patricia Lemarchand, Michel De Waard
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
BeKm-1
hERG
LQTS
hiPS-cardiomyocytes
Online Access:https://www.mdpi.com/1422-0067/21/19/7167

Internet

https://www.mdpi.com/1422-0067/21/19/7167

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