Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/ApoE Double Knockout Mice: Differential Cardiovascular Outcome

Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/ApoE Double Knockout Mice: Differential Cardiovascular Outcome

Sterol 27-hydroxylase (CYP27A1) is a key enzyme in bile acids (BAs) biosynthesis and a regulator of cholesterol metabolism. Cyp27a1/Apolipoprotein E double knockout (DKO) mice fed with western diet (WD) are protected from atherosclerosis via up-regulation of hepatic Cyp7a1 and Cyp3a11. Since feeding...

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Bibliographic Details
Main Authors: Line Zurkinden, Dmitri Sviridov, Bruno Vogt, Genevieve Escher
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Endocrinology
Subjects:
bile acids
Western diet
sterol 27-hydroxylase
cholesterol absorption
LDL-cholesterol
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.586980/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2020.586980/full

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