Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.

Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.

Class switch DNA recombination (CSR) of the immunoglobulin heavy chain (IgH) locus crucially diversifies antibody biological effector functions. CSR involves the induction of activation-induced cytidine deaminase (AID) expression and AID targeting to switch (S) regions by 14-3-3 adaptors. 14-3-3 ada...

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Bibliographic Details
Main Authors: Tonika Lam, Lisa M Thomas, Clayton A White, Guideng Li, Egest J Pone, Zhenming Xu, Paolo Casali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24282540/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24282540/pdf/?tool=EBI

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