The anoikis effector Bit1 displays tumor suppressive function in lung cancer cells.

The anoikis effector Bit1 displays tumor suppressive function in lung cancer cells.

The mitochondrial Bit1 (Bcl-2 inhibitor of transcription 1) protein is a part of an apoptotic pathway that is uniquely regulated by integrin-mediated attachment. As an anoikis effector, Bit1 is released into the cytoplasm following loss of cell attachment and induces a caspase-independent form of ap...

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Bibliographic Details
Main Authors: Xin Yao, Scott Jennings, Shubha Kale Ireland, Tri Pham, Brandi Temple, Mya Davis, Renwei Chen, Ian Davenport, Hector Biliran
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4086906?pdf=render

Internet

http://europepmc.org/articles/PMC4086906?pdf=render

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