A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction

A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction

Conjugated polyenes are a class of widely occurring natural products with various biological functions. We previously identified 4-hydroxy auxarconjugatin B (4-HAB) as anti‐inflammatory agent with an IC50 of ~20 µM. In this study, we synthesized a new anti‐inflammatory 4-HAB analogue, F240B, which h...

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Bibliographic Details
Main Authors: Chun-Hsien Wu, Chin Heng Gan, Lan-Hui Li, Jen-Che Chang, Shin-Tai Chen, Mridula P. Menon, Shu-Meng Cheng, Shih-Ping Yang, Chen-Lung Ho, Oleg V. Chernikov, Chi-Hung Lin, Yulin Lam, Kuo-Feng Hua
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
NLRP3 inflammasome
conjugated polyenes
autophagy
mitochondria
peritonitis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.607564/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.607564/full

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