Aminoglycoside 6′-<i>N</i>-acetyltransferase Type Ib [AAC(6′)-Ib]-Mediated Aminoglycoside Resistance: Phenotypic Conversion to Susceptibility by Silver Ions

Aminoglycoside 6′-<i>N</i>-acetyltransferase Type Ib [AAC(6′)-Ib]-Mediated Aminoglycoside Resistance: Phenotypic Conversion to Susceptibility by Silver Ions

Clinical resistance to amikacin and other aminoglycosides is usually due to the enzymatic acetylation of the antimicrobial molecule. A ubiquitous resistance enzyme among Gram-negatives is the aminoglycoside 6′-<i>N</i>-acetyltransferase type Ib [AAC(6′)-Ib], which catalyzes acetylation u...

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Bibliographic Details
Main Authors: Craig M. Reeves, Jesus Magallon, Kenneth Rocha, Tung Tran, Kimberly Phan, Peter Vu, Yang Yi, Crista L. Oakley-Havens, José Cedano, Verónica Jimenez, Maria S. Ramirez, Marcelo E. Tolmasky
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antibiotics
Subjects:
ESKAPE
<i>Acinetobacter</i>
aminoglycosides
amikacin
acetyltransferase
silver
Online Access:https://www.mdpi.com/2079-6382/10/1/29

Internet

https://www.mdpi.com/2079-6382/10/1/29

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