Systemic inflammation, blood-brain barrier vulnerability and cognitive / non-cognitive symptoms in Alzheimer disease: Relevance to pathogenesis and therapy

Systemic inflammation, blood-brain barrier vulnerability and cognitive / non-cognitive symptoms in Alzheimer disease: Relevance to pathogenesis and therapy

The incidence of dementia is increasing at an alarming rate, and has become a major public health concern. Alzheimer disease (AD) is the most common form of dementia and is characterized by progressive cognitive impairment. In addition to classical neuropathological features such as amyloid plaques...

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Bibliographic Details
Main Authors: Shuko eTakeda, Naoyuki eSato, Ryuichi eMorishita
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer Disease
Blood-Brain Barrier
Therapeutics
Pathogenesis
systemic inflammation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00171/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00171/full

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