Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms.

Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms.

Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity in patients. Several transgenic animal platforms are available for the generation of fully human mAbs. Attributes such as specificity, efficacy and C...

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Main Authors: Beatrice Cameron, Tarik Dabdoubi, Laurence Berthou-Soulié, Marie Gagnaire, Isabelle Arnould, Anne Severac, Fabienne Soubrier, Jacqueline Morales, Philip A Leighton, William Harriman, Kathryn Ching, Yasmina Abdiche, Katarina Radošević, Thomas Bouquin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0235815

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https://doi.org/10.1371/journal.pone.0235815

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