PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium tuberculosis

Iron is essential for replication of Mycobacterium tuberculosis, but iron is efficiently sequestered in the human host during infection. Heme constitutes the largest iron reservoir in the human body and is utilized by many bacterial pathogens as an iron source. While heme acquisition is well studied...

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Bibliographic Details
Main Authors: Avishek Mitra, Alexander Speer, Kan Lin, Sabine Ehrt, Michael Niederweis, Christina L. Stallings
Format: Article
Language:English
Published: American Society for Microbiology 2017-01-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/1/e01720-16