Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy.

Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy.

AIMS/HYPOTHESIS:We hypothesized that diabetes during pregnancy (DDP) alters genome-wide DNA methylation in placenta resulting in differentially methylated loci of metabolically relevant genes and downstream changes in RNA and protein expression. METHODS:We mapped genome-wide DNA methylation with the...

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Bibliographic Details
Main Authors: Jacqueline Alexander, April M Teague, Jing Chen, Christopher E Aston, Yuet-Kin Leung, Steven Chernausek, Rebecca A Simmons, Sara E Pinney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5823368?pdf=render

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http://europepmc.org/articles/PMC5823368?pdf=render

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