Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection

Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection

Summary: Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying mechanisms are unclear. Using models of physiological and dysregulated IFNα/β receptor (IFNAR1) surface express...

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Bibliographic Details
Main Authors: Konrad C. Bradley, Katja Finsterbusch, Daniel Schnepf, Stefania Crotta, Miriam Llorian, Sophia Davidson, Serge Y. Fuchs, Peter Staeheli, Andreas Wack
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719307442

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