Rat hypocretin/orexin neurons are maintained in a depolarized state by TRPC channels.

Rat hypocretin/orexin neurons are maintained in a depolarized state by TRPC channels.

In a previous study we proposed that the depolarized state of the wake-promoting hypocretin/orexin (hcrt/orx) neurons was independent of synaptic inputs as it persisted in tetrodotoxin and low calcium/high magnesium solutions. Here we show first that these cells are hyperpolarized when external sodi...

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Bibliographic Details
Main Authors: Vesna Cvetkovic-Lopes, Emmanuel Eggermann, Aaron Uschakov, Jeremy Grivel, Laurence Bayer, Barbara E Jones, Mauro Serafin, Michel Mühlethaler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3002943?pdf=render

Internet

http://europepmc.org/articles/PMC3002943?pdf=render

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