<i>ABL</i> Genomic Editing Sufficiently Abolishes Oncogenesis of Human Chronic Myeloid Leukemia Cells In Vitro and In Vivo

<i>ABL</i> Genomic Editing Sufficiently Abolishes Oncogenesis of Human Chronic Myeloid Leukemia Cells In Vitro and In Vivo

Chronic myelogenous leukemia (CML) is the most common type of leukemia in adults, and more than 90% of CML patients harbor the abnormal Philadelphia chromosome (Ph) that encodes the BCR-ABL oncoprotein. Although the ABL kinase inhibitor (imatinib) has proven to be very effective in achieving high re...

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Bibliographic Details
Main Authors: Shu-Huey Chen, Yao-Yu Hsieh, Huey-En Tzeng, Chun-Yu Lin, Kai-Wen Hsu, Yun-Shan Chiang, Su-Mei Lin, Ming-Jang Su, Wen-Shyang Hsieh, Chia-Hwa Lee
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
CRISPR/Cas9
gene edit
Philadelphia chromosome
BCR-ABL
CML
Online Access:https://www.mdpi.com/2072-6694/12/6/1399

Internet

https://www.mdpi.com/2072-6694/12/6/1399

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