Analogs of a Natural Peptaibol Exert Anticancer Activity in Both Cisplatin- and Doxorubicin-Resistant Cells and in Multicellular Tumor Spheroids

Analogs of a Natural Peptaibol Exert Anticancer Activity in Both Cisplatin- and Doxorubicin-Resistant Cells and in Multicellular Tumor Spheroids

Peptaibols, by disturbing the permeability of phospholipid membranes, can overcome anticancer drug resistance, but their natural hydrophobicity hampers their administration. By a green peptide synthesis protocol, we produced two water-soluble analogs of the peptaibol trichogin GA IV, termed K6-Lol a...

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Bibliographic Details
Main Authors: Naike Casagrande, Cinzia Borghese, Laura Gabbatore, Laura Morbiato, Marta De Zotti, Donatella Aldinucci
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
anticancer peptide
alpha-helix
drug-resistant tumors
Hodgkin lymphoma
ovarian cancer
multicellular tumor spheroids
Online Access:https://www.mdpi.com/1422-0067/22/16/8362

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https://www.mdpi.com/1422-0067/22/16/8362

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