Loratadine bioavailability via buccal transferosomal gel: formulation, statistical optimization, in vitro/in vivo characterization, and pharmacokinetics in human volunteers

Loratadine bioavailability via buccal transferosomal gel: formulation, statistical optimization, in vitro/in vivo characterization, and pharmacokinetics in human volunteers

Loratadine (LTD) is an antihistaminic drug that suffers limited solubility, poor oral bioavailability (owing to extensive first-pass metabolism), and highly variable oral absorption. This study was undertaken to develop and statistically optimize transfersomal gel for transbuccal delivery of LTD. Tr...

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Bibliographic Details
Main Authors: Mohammed H. Elkomy, Shahira F. El Menshawe, Heba A. Abou-Taleb, Marwa H. Elkarmalawy
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Drug Delivery
Subjects:
loratadine
transferosomes
buccal
mucoadhesive gel
bioavailability
Online Access:http://dx.doi.org/10.1080/10717544.2017.1321061

Internet

http://dx.doi.org/10.1080/10717544.2017.1321061

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