Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66Shc-/- mouse

Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66Shc-/- mouse

Metabolic stressful challenges during susceptible time windows, such as fetal life, can have important implications for health throughout life. Deletion of the p66Shc gene in mice leads to reduced oxidative stress, resulting in a healthy and lean phenotype characterized by increased metabolic rate,...

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Bibliographic Details
Main Authors: Veronica eBellisario, Alessandra eBerry, Sara eCapoccia, Carla eRaggi, Pamela ePanetta, Igor eBranchi, Giovanni ePiccaro, Marco eGiorgio, Pier Giuseppe ePelicci, Francesca eCirulli
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Adipokines
Biomarkers, Pharmacological
Oxidative Stress
gender differences
Animal Models
emotionality
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00285/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00285/full

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