Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability

Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability

P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse structures out of cells, resulting in poor intestinal permeation and limited bioavailability following oral administration. P-gp inhibitors, including small molecule drugs, natural constituents, and pharmaceu...

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Bibliographic Details
Main Authors: Thi-Thao-Linh Nguyen, Van-An Duong, Han-Joo Maeng
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
P-gp
inhibitors
permeability
drug delivery
solid lipid nanoparticles
micelles
Online Access:https://www.mdpi.com/1999-4923/13/7/1103

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https://www.mdpi.com/1999-4923/13/7/1103

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