Isoniazid causes heart looping disorder in zebrafish embryos by the induction of oxidative stress

Isoniazid causes heart looping disorder in zebrafish embryos by the induction of oxidative stress

Abstract Background The cardiotoxicity of isoniazid on zebrafish embryos and its underlying mechanism is unclear. Methods Here, we exposed zebrafish embryos at 4 h post-fertilization to different levels of isoniazid and recorded the morphology and number of malformed and dead embryos under the micro...

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Bibliographic Details
Main Authors: Jie Ni, Hongye Wang, Xiyi Wei, Kangjie Shen, Yeqin Sha, Yuxiang Dong, Yimei Shu, Xiaojie Wan, Jingwen Cheng, Fang Wang, Yihai Liu
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Pharmacology and Toxicology
Subjects:
Isoniazid
Heart looping disorder
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s40360-020-0399-2

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http://link.springer.com/article/10.1186/s40360-020-0399-2

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