PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice.

PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice.

Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), an aggressive malignant proliferation of activated CD4+ T lymphocytes. The viral Tax oncoprotein is critically involved in both HTLV-1-replication and T-cell proliferation, a prerequisite t...

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Bibliographic Details
Main Authors: Eléonore Pérès, Juliana Blin, Emiliano P Ricci, Maria Artesi, Vincent Hahaut, Anne Van den Broeke, Antoine Corbin, Louis Gazzolo, Lee Ratner, Pierre Jalinot, Madeleine Duc Dodon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5882172?pdf=render

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http://europepmc.org/articles/PMC5882172?pdf=render

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