HIV-1 tolerates changes in A-count in a small segment of the pol gene

Abstract Background The HIV-1 RNA genome has a biased nucleotide composition with a surplus of As. Several hypotheses have been put forward to explain this striking phenomenon, but the A-count of the HIV-1 genome has thus far not been systematically manipulated. The reason for this reservation is th...

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Bibliographic Details
Main Authors: Bep Klaver, Yme van der Velden, Formijn van Hemert, Antoinette C. van der Kuyl, Ben Berkhout
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Retrovirology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12977-017-0367-0