Homocysteine Causes Endothelial Dysfunction via Inflammatory Factor-Mediated Activation of Epithelial Sodium Channel (ENaC)

Homocysteine Causes Endothelial Dysfunction via Inflammatory Factor-Mediated Activation of Epithelial Sodium Channel (ENaC)

BackgroundHyperhomocysteinemia (HHcy) causes cardiovascular diseases via regulating inflammatory responses. We investigated whether and how the epithelial sodium channel (ENaC), a recently identified ion channel in endothelial cells, plays a role in HHcy-induced endothelial dysfunction.MethodsCell-a...

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Bibliographic Details
Main Authors: Chen Liang, Qiu-Shi Wang, Xu Yang, Di Zhu, Yu Sun, Na Niu, Jie Yao, Bi-Han Dong, Shuai Jiang, Liang-Liang Tang, Jie Lou, Chang-Jiang Yu, Qun Shao, Ming-Ming Wu, Zhi-Ren Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hyperhomocysteinemia
endothelial epithelial sodium channel
inflammation and cyclooxygenase-2
reactive oxygen species
vascular dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.672335/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.672335/full

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