Physical basis of the ‘magnification rule’ for standardized Immunohistochemical scoring of HER2 in breast and gastric cancer

Physical basis of the ‘magnification rule’ for standardized Immunohistochemical scoring of HER2 in breast and gastric cancer

Abstract Background Detection of HER2/neu receptor overexpression and/or amplification is a prerequisite for efficient anti-HER2 treatment of breast and gastric carcinomas. Immunohistochemistry (IHC) of the HER2 protein is the most common screening test, thus precise and reproducible IHC-scoring is...

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Bibliographic Details
Main Authors: Andreas H. Scheel, Frédérique Penault-Llorca, Wedad Hanna, Gustavo Baretton, Peter Middel, Judith Burchhardt, Manfred Hofmann, Bharat Jasani, Josef Rüschoff
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Diagnostic Pathology
Subjects:
HER2/neu
Immunohistochemistry
Breast cancer
Gastric cancer
Magnification rule
Predictive biomarker
Online Access:http://link.springer.com/article/10.1186/s13000-018-0696-x

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http://link.springer.com/article/10.1186/s13000-018-0696-x

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