Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation

Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation

Group 3 innate lymphoid cells (ILC3s) have important functions in inflammatory bowel disease. Here, the authors show that TL1A/DR3 signalling stimulates ILC3s to produce GM-CSF, thereby recruiting inflammatory cells, which results in subsequent IL-23-dependent loss of ILC3s and further intestinal in...

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Bibliographic Details
Main Authors: Jingyu Li, Wenli Shi, Hanxiao Sun, Yan Ji, Yuqin Chen, Xiaohuan Guo, Huiming Sheng, Jie Shu, Liang Zhou, Ting Cai, Ju Qiu
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11304-8

Internet

https://doi.org/10.1038/s41467-019-11304-8

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