PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs.

PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs.

Preferentially expressed antigen in melanoma (PRAME) has been described as a cancer-testis antigen and is associated with leukaemias and solid tumours. Here we show that PRAME gene transcription in leukaemic cell lines is rapidly induced by exposure of cells to bacterial PAMPs (pathogen associated m...

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Bibliographic Details
Main Authors: Frances R Wadelin, Joel Fulton, Hilary M Collins, Nikolaos Tertipis, Andrew Bottley, Keith A Spriggs, Franco H Falcone, David M Heery
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3584020?pdf=render

Internet

http://europepmc.org/articles/PMC3584020?pdf=render

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