Optimization of New Catalytic Topoisomerase II Inhibitors as an Anti-Cancer Therapy

Optimization of New Catalytic Topoisomerase II Inhibitors as an Anti-Cancer Therapy

Clinically used topoisomerase II (TOP2) inhibitors are poison inhibitors that induce DNA damage to cause cancer cell death. However, they can also destroy benign cells and thereby show serious side effects, including cardiotoxicity and drug-induced secondary malignancy. New TOP2 inhibitors with a di...

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Bibliographic Details
Main Authors: Victor M. Matias-Barrios, Mariia Radaeva, Chia-Hao Ho, Joseph Lee, Hans Adomat, Nada Lallous, Artem Cherkasov, Xuesen Dong
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
topoisomerase II
catalytic inhibitor
computer-aided drug design
cytotoxicity
DNA binding blocker
Online Access:https://www.mdpi.com/2072-6694/13/15/3675

Internet

https://www.mdpi.com/2072-6694/13/15/3675

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