CD34T+ Humanized Mouse Model to Study Mucosal HIV-1 Transmission and Prevention

CD34T+ Humanized Mouse Model to Study Mucosal HIV-1 Transmission and Prevention

Humanized mice are critical for HIV-1 research, but humanized mice generated from cord blood are inefficient at mucosal HIV-1 transmission. Most mucosal HIV-1 transmission studies in mice require fetal tissue-engraftment, the use of which is highly restricted or prohibited. We present a fetal tissue...

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Bibliographic Details
Main Authors: Kanika Vanshylla, Kathrin Held, Tabea M. Eser, Henning Gruell, Franziska Kleipass, Ricarda Stumpf, Kanika Jain, Daniela Weiland, Jan Münch, Berthold Grüttner, Christof Geldmacher, Florian Klein
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Vaccines
Subjects:
humanized mice
mucosal HIV-1 prevention
broadly neutralizing antibodies
Online Access:https://www.mdpi.com/2076-393X/9/3/198

Internet

https://www.mdpi.com/2076-393X/9/3/198

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