Administration of a Histone Deacetylase Inhibitor into the Basolateral Amygdala Enhances Memory Consolidation, Delays Extinction, and Increases Hippocampal BDNF Levels

Administration of a Histone Deacetylase Inhibitor into the Basolateral Amygdala Enhances Memory Consolidation, Delays Extinction, and Increases Hippocampal BDNF Levels

Gene expression related to the formation and modification of memories is regulated epigenetically by chromatin remodeling through histone acetylation. Memory formation and extinction can be enhanced by treatment with inhibitors of histone deacetylases (HDACs). The basolateral amygdala (BLA) is a bra...

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Bibliographic Details
Main Authors: Fernanda E. Valiati, Mailton Vasconcelos, Martina Lichtenfels, Fernanda S. Petry, Rosa M. M. de Almeida, Gilberto Schwartsmann, Nadja Schröder, Caroline B. de Farias, Rafael Roesler
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Pharmacology
Subjects:
histone deacetylase
brain-derived neurotrophic factor
amygdala
hippocampus
memory extinction
memory consolidation
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00415/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00415/full

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