Allosteric Modulation of GABAA Receptors by an Anilino Enaminone in an Olfactory Center of the Mouse Brain

Allosteric Modulation of GABAA Receptors by an Anilino Enaminone in an Olfactory Center of the Mouse Brain

In an ongoing effort to identify novel drugs that can be used as neurotherapeutic compounds, we have focused on anilino enaminones as potential anticonvulsant agents. Enaminones are organic compounds containing a conjugated system of an amine, an alkene and a ketone. Here, we review the effects of a...

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Bibliographic Details
Main Authors: Thomas Heinbockel, Ze-Jun Wang, Patrice L. Jackson-Ayotunde
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:Pharmaceuticals
Subjects:
anticonvulsant
brain slice
enaminone
GABA
GABAA receptor
inhibition
mitral cell
neuromodulation
olfactory bulb
positive allosteric modulator
Online Access:http://www.mdpi.com/1424-8247/7/12/1069

Internet

http://www.mdpi.com/1424-8247/7/12/1069

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