Predictors of the onset of manic symptoms and a (hypo)manic episode in patients with major depressive disorder.

OBJECTIVE: One third of patients with a major depressive episode also experience manic symptoms or, even, a (hypo)manic episode. Retrospective studies on the temporal sequencing of symptomatology suggest that the majority of these patients report depressive symptoms before the onset of manic symptom...

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Bibliographic Details
Main Authors: Lynn Boschloo, Annet T Spijker, Erik Hoencamp, Ralph Kupka, Willem A Nolen, Robert A Schoevers, Brenda W J H Penninx
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4178019?pdf=render