Soluble Cytoplasmic Expression and Purification of Immunotoxin HER2(scFv)-PE24B as a Maltose Binding Protein Fusion

Soluble Cytoplasmic Expression and Purification of Immunotoxin HER2(scFv)-PE24B as a Maltose Binding Protein Fusion

Human epidermal growth factor receptor 2 (HER-2) is overexpressed in many malignant tumors. The anti-HER2 antibody trastuzumab has been approved for treating HER2-positive early and metastatic breast cancers. <i>Pseudomonas</i> exotoxin A (PE), a bacterial toxin of <i>Pseudomonas a...

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Bibliographic Details
Main Authors: Sangsu Park, Minh Quan Nguyen, Huynh Kim Khanh Ta, Minh Tan Nguyen, Gunsup Lee, Chong Jai Kim, Yeon Jin Jang, Han Choe
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
protein expression
protein purification
immunotoxin
HER2(scFv)-PE24B
maltose binding protein
trastuzumab
Online Access:https://www.mdpi.com/1422-0067/22/12/6483

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https://www.mdpi.com/1422-0067/22/12/6483

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