Updating the modified Thompson test by using whole-body bioluminescence imaging to replace traditional efficacy testing in experimental models of murine malaria

Updating the modified Thompson test by using whole-body bioluminescence imaging to replace traditional efficacy testing in experimental models of murine malaria

Abstract Background Rodent malaria models are extensively used to predict treatment outcomes in human infections. There is a constant need to improve and refine these models by innovating ways to apply new scientific findings and cutting edge technologies. In addition, and in accordance with the thr...

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Bibliographic Details
Main Authors: Diana Caridha, Mark Hickman, Lisa Xie, Franklyn Ngundam, Erin Milner, Amanda Schenk, Kirk Butler, Dylan Nugent, Patricia Lee, Norma Roncal, Susan Leed, Eve Hosford, Jangwoo Lee, Richard J. Sciotti, Gregory Reichard, Chad Black, Mara Kreishman-Deitrick, Qigui Li, Brian Vesely
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Malaria Journal
Subjects:
Plasmodium berghei
Animal models
Refinement
Parasite load predicted parasitaemia (PLPP)
Anti-malarial drugs
Preemptive euthanasia
Online Access:http://link.springer.com/article/10.1186/s12936-019-2661-x

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http://link.springer.com/article/10.1186/s12936-019-2661-x

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