Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Aβ42 in response to tunicamycin

Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Aβ42 in response to tunicamycin

Many patients affected by early onset familial Alzheimer's disease (FAD), carry mutations in the presenilin 1 (PS1) gene. Since it has been suggested that FAD-linked PS1 mutations impair the unfolded protein response (UPR) due to endoplasmic reticulum (ER) stress, we analyzed the UPR and amyloi...

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Bibliographic Details
Main Authors: Alessandra Piccini, Anna Fassio, Elena Pasqualetto, Antonella Vitali, Roberta Borghi, Daniela Palmieri, Benedetta Nacmias, Sandro Sorbi, Roberto Sitia, Massimo Tabaton
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Neurobiology of Disease
Subjects:
Presenilin
Alzheimer's disease
Endoplasmic reticulum
Amyloid
Unfolding protein response
Primary fibroblasts
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610300250X

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http://www.sciencedirect.com/science/article/pii/S096999610300250X

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