Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis

Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis

Abstract Introduction Abnormal glycolytic metabolism contributes to joint inflammation and destruction in rheumatoid arthritis (RA). We examine the expression and function of hexokinases in RA and evaluate the potential of their specific inhibitor for clinical treatment. Methods Detection of HKs was...

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Bibliographic Details
Main Authors: Guanhua Song, Qiqi Lu, Hua Fan, Xiumei Zhang, Luna Ge, Ruisong Tian, Shiguan Wang, Tingting Feng, Jihong Pan, Jingjing Feng, Yabo Xiao, Xin Yi, Ningxin Ren, Lin Wang
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Inflammation
Hypoxia
Glycolysis
Hexokinase
Lonidamine
Online Access:http://link.springer.com/article/10.1186/s13075-019-1865-3

Internet

http://link.springer.com/article/10.1186/s13075-019-1865-3

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