Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory

Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory

Group I metabotropic glutamate receptors, in particular mGluR5, have been implicated in various forms of synaptic plasticity that are believed to underlie declarative memory. We observed that mGluR5 specifically activated a channel containing TRPC1, an isoform of the canonical family of transient re...

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Bibliographic Details
Main Authors: Sophie Lepannetier, Roberta Gualdani, Sabrina Tempesta, Olivier Schakman, François Seghers, Anna Kreis, Xavier Yerna, Amina Slimi, Marie de Clippele, Nicolas Tajeddine, Thomas Voets, Robin S. Bon, David J. Beech, Fadel Tissir, Philippe Gailly
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
mGluR
TRP channels
synaptic plasticity
spatial memory
hippocampus
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00318/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00318/full

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