Liver X Receptors Suppress Activity of Cholesterol and Fatty Acid Synthesis Pathways To Oppose Gammaherpesvirus Replication

Gammaherpesviruses are oncogenic pathogens that persist in ~95% of the adult population. Cellular metabolic pathways have emerged as important regulators of many viral infections, including infections by gammaherpesviruses that require several lipid synthetic pathways for optimal replication. Liver...

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Bibliographic Details
Main Authors: P. T. Lange, C. Schorl, D. Sahoo, V. L. Tarakanova
Format: Article
Language:English
Published: American Society for Microbiology 2018-07-01
Series:mBio
Subjects:
Online Access:https://doi.org/10.1128/mBio.01115-18