Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss

Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss

Abstract Background Loss of pancreatic insulin-secreting β-cells due to metabolic or autoimmune damage leads to the development of diabetes. The discovery that α-cells can be efficiently reprogrammed into insulin-secreting cells in mice and humans has opened promising avenues for innovative diabetes...

Full description

Bibliographic Details
Main Authors: Daniel Oropeza, Valentina Cigliola, Agustín Romero, Simona Chera, Santiago A. Rodríguez-Seguí, Pedro L. Herrera
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Genomics
Subjects:
Alpha cell
Beta cell
Pancreas
Pancreatic islet
Conversion
RNA-seq
Online Access:https://doi.org/10.1186/s12864-021-07812-x

Internet

https://doi.org/10.1186/s12864-021-07812-x

Similar Items