Novel Cre-Expressing Mouse Strains Permitting to Selectively Track and Edit Type 1 Conventional Dendritic Cells Facilitate Disentangling Their Complexity in vivo

Novel Cre-Expressing Mouse Strains Permitting to Selectively Track and Edit Type 1 Conventional Dendritic Cells Facilitate Disentangling Their Complexity in vivo

Type 1 conventional DCs (cDC1) excel in the cross-priming of CD8+ T cells, which is crucial for orchestrating efficient immune responses against viruses or tumors. However, our understanding of their physiological functions and molecular regulation has been limited by the lack of proper mutant mouse...

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Bibliographic Details
Main Authors: Raphaël Mattiuz, Christian Wohn, Sonia Ghilas, Marc Ambrosini, Yannick O. Alexandre, Cindy Sanchez, Anissa Fries, Thien-Phong Vu Manh, Bernard Malissen, Marc Dalod, Karine Crozat
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
cDC1
XCR1
Gp141b
Karma
Clec9a
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02805/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02805/full

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