Differences in Functional Expression of Connexin43 and NaV1.5 by Pan- and Class-Selective Histone Deacetylase Inhibition in Heart

Differences in Functional Expression of Connexin43 and NaV1.5 by Pan- and Class-Selective Histone Deacetylase Inhibition in Heart

Class-selective histone deacetylase (HDAC) inhibitors were designed to improve safety profiles and therapeutic effectiveness in the treatment of multiple cancers relative to pan-HDAC inhibitors. However, the underlying mechanisms for their therapeutic and cardiotoxic potentials remain poorly underst...

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Bibliographic Details
Main Authors: Xian Zhang, Dakshesh Patel, Qin Xu, Richard Veenstra
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
histone deacetylase inhibitors
class-selective
gap junction
cardiac sodium channel
connexin43
NaV1.5
cardiotoxicity
Online Access:http://www.mdpi.com/1422-0067/19/8/2288

Internet

http://www.mdpi.com/1422-0067/19/8/2288

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