Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch

Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch

Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation of CK1 in eukaryotes, little is known about its regulation and the factors that influence substrate selectivity on func...

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Bibliographic Details
Main Authors: Jonathan M Philpott, Rajesh Narasimamurthy, Clarisse G Ricci, Alfred M Freeberg, Sabrina R Hunt, Lauren E Yee, Rebecca S Pelofsky, Sarvind Tripathi, David M Virshup, Carrie L Partch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
in vitro biochemistry
human cell culture
mouse cell culture
protiens
Online Access:https://elifesciences.org/articles/52343

Internet

https://elifesciences.org/articles/52343

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