E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3K/Akt pathway

E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3K/Akt pathway

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Arsenic trioxide (ATO) is a strong inducer of apoptosis in malignant hematological cells. Inducible phosphatidyl inositol 3 kinase (PI3K)-Akt activation promotes resistance to ATO. In the present study, we evaluated whether E3 ubiquitin ligase Cbl-b, a negative regulator of PI3K activation, is invol...

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Bibliographic Details
Main Authors: Li Yingchun, Qu Xiujuan, Qu Jinglei, Zhang Ye, Liu Jing, Teng Yuee, Hu Xuejun, Hou Kezuo, Liu Yunpeng
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2011-02-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Arsenic trioxide
Apoptosis
Cbl-b
PI3K/Akt pathway
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200004

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200004

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