The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission

The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission

Neurotransmission is a tightly regulated Ca2+-dependent process. Upon Ca2+ influx, Synaptotagmin1 (Syt1) promotes fusion of synaptic vesicles (SVs) with the plasma membrane. This requires regulation at multiple levels, but the role of metabolites in SV release is unclear. Here, we uncover a role for...

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Bibliographic Details
Main Authors: Berrak Ugur, Huan Bao, Michal Stawarski, Lita R. Duraine, Zhongyuan Zuo, Yong Qi Lin, G. Gregory Neely, Gregory T. Macleod, Edwin R. Chapman, Hugo J. Bellen
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
tricarboxylic acid cycle
TCA
alpha-ketoglutarate
αKG
synaptotagmin
exocytosis
Syt1
endocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717318016

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http://www.sciencedirect.com/science/article/pii/S2211124717318016

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