Influence of γ-Secretase Inhibitor 24-Diamino-5-Phenylthiazole DAPT on Platelet Activation

Influence of γ-Secretase Inhibitor 24-Diamino-5-Phenylthiazole DAPT on Platelet Activation

Background/Aims: DAPT (24-diamino-5-phenylthiazole) inhibits γ-secretase, which cleaves the signaling molecule CD44, a negative regulator of platelet activation and apoptosis. CD44 is a co-receptor for macrophage migration inhibitory factor (MIF) an anti-apoptotic pro-inflammatory cytokine...

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Bibliographic Details
Main Authors: Guoxing Liu, Guilai Liu, Madhumita Chatterjee, Anja T. Umbach, Hong Chen, Meinrad Gawaz, Florian Lang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Integrin activation
Reactive oxygen species
Phosphatidylserine translocation
Cytosolic Ca2+ concentration
Platelet activation
Platelet degranulation
Collagen related peptide
Online Access:http://www.karger.com/Article/FullText/443029

Internet

http://www.karger.com/Article/FullText/443029

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