Downregulation of XBP1 protects kidney against ischemia-reperfusion injury via suppressing HRD1-mediated NRF2 ubiquitylation

Downregulation of XBP1 protects kidney against ischemia-reperfusion injury via suppressing HRD1-mediated NRF2 ubiquitylation

Abstract Ischemia-reperfusion (IR) injury to the renal epithelia is associated with endoplasmic reticulum stress (ERS) and mitochondria dysfunction, which lead to oxidative stress-induced acute kidney injury (AKI). X-box binding protein 1 (XBP1), an ERS response protein, could play a prominent role...

Full description

Bibliographic Details
Main Authors: Ji Zhang, Jiasi Zhang, Haiqiang Ni, Yanfeng Wang, Gaurav Katwal, Yuanyuan Zhao, Kailun Sun, Mengqin Wang, Qingwen Li, Gen Chen, Yun Miao, Nianqiao Gong
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00425-z

Internet

https://doi.org/10.1038/s41420-021-00425-z

Similar Items