Early-Stage Induction of SWI/SNF Mutations during Esophageal Squamous Cell Carcinogenesis.

The SWI/SNF chromatin remodeling complex is frequently inactivated by somatic mutations of its various components in various types of cancers, and also by aberrant DNA methylation. However, its somatic mutations and aberrant methylation in esophageal squamous cell carcinomas (ESCCs) have not been fu...

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Main Authors: Hidetsugu Nakazato, Hideyuki Takeshima, Takayoshi Kishino, Emi Kubo, Naoko Hattori, Takeshi Nakajima, Satoshi Yamashita, Hiroyasu Igaki, Yuji Tachimori, Yukio Kuniyoshi, Toshikazu Ushijima
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4728064?pdf=render