Omega-3 Polyunsaturated Fatty Acids Alleviate Traumatic Brain Injury by Regulating the Glymphatic Pathway in Mice

Omega-3 Polyunsaturated Fatty Acids Alleviate Traumatic Brain Injury by Regulating the Glymphatic Pathway in Mice

Background: The glymphatic pathway has been shown to be impaired in traumatic brain injury (TBI). Omega-3 polysaturated fatty acids (Omega-3, PUFAs) are involved in the clearance of amyloid-ß through the glymphatic system and this effect is Aquaporin-4 (AQP4) dependent. We hypothesize that Omega-3 P...

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Bibliographic Details
Main Authors: Erwei Zhang, Xiangdong Wan, Lijun Yang, Dong Wang, Zeshang Chen, Yan Chen, Minghao Liu, Gengshen Zhang, Jianliang Wu, Haie Han, Zhenzeng Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Neurology
Subjects:
omega-3 polyunsaturated fatty acid
traumatic brain injury
glymphatic system
aquaporin-4
blood-brain barrier
epilepsy
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00707/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2020.00707/full

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