Neoadjuvant Use of Oncolytic Herpes Virus G47Δ Enhances the Antitumor Efficacy of Radiofrequency Ablation

Neoadjuvant Use of Oncolytic Herpes Virus G47Δ Enhances the Antitumor Efficacy of Radiofrequency Ablation

G47Δ is a triple-mutated oncolytic herpes simplex virus type 1 designed to induce antitumor immune responses efficiently. We examine the usefulness of G47Δ as a neoadjuvant therapy for radiofrequency ablation (RFA), a standard local treatment for certain cancers such as liver cancer, but remote recu...

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Bibliographic Details
Main Authors: Tomoharu Yamada, Ryosuke Tateishi, Miwako Iwai, Kazuhiko Koike, Tomoki Todo
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
Oncolytic virus
G47Δ
radiofrequency ablation
hepatocellular carcinoma
immune checkpoint inhibitor
herpes simplex virus type 1
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520301273

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http://www.sciencedirect.com/science/article/pii/S2372770520301273

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