A Novel Aspect of Tumorigenesis—BMI1 Functions in Regulating DNA Damage Response

A Novel Aspect of Tumorigenesis—BMI1 Functions in Regulating DNA Damage Response

BMI1 plays critical roles in maintaining the self-renewal of hematopoietic, neural, intestinal stem cells, and cancer stem cells (CSCs) for a variety of cancer types. BMI1 promotes cell proliferative life span and epithelial to mesenchymal transition (EMT). Upregulation of BMI1 occurs in multiple ca...

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Bibliographic Details
Main Authors: Xiaozeng Lin, Diane Ojo, Fengxiang Wei, Nicholas Wong, Yan Gu, Damu Tang
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Biomolecules
Subjects:
BMI1
histone ubiquitination
DNA damage response (DDR)
ATM
γH2AX
H2A
repair of double-stranded DNA breaks
checkpoint activation
Online Access:http://www.mdpi.com/2218-273X/5/4/3396

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http://www.mdpi.com/2218-273X/5/4/3396

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