Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

Summary: Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder that often presents with psychiatric conditions, including autism spectrum disorder (ASD). ASD is characterized by restricted, repetitive, and inflexible behaviors, which may result from abnormal activity in striatal circuits...

Full description

Bibliographic Details
Main Authors: Katelyn N. Benthall, Katherine R. Cording, Alexander H.C.W. Agopyan-Miu, Corinna D. Wong, Emily Y. Chen, Helen S. Bateup
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
Tuberous Sclerosis Complex
Tsc1
Tsc2
striatum
direct pathway
indirect pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721009414

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721009414

Similar Items