TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread

Controlled cell death can be an efficient anti-viral strategy, but also leads to tissue damage and needs to be balanced. Oyler-Yaniv et al. combine mathematical modelling and microscopy to show that exposure to TNF in response to viral infection causes cells to tune their speed-vs-accuracy trade-off...

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Bibliographic Details
Main Authors: Jennifer Oyler-Yaniv, Alon Oyler-Yaniv, Evan Maltz, Roy Wollman
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23195-9